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Maleimide Peg NHS Ester contains both a maleimide functional group (-Mal) and an N-hydroxysuccinimide (NHS) ester group attached to a PEG chain. The maleimide group is known for its ability to react with thiol groups on proteins and peptides, while the NHS ester group can react with primary amines, making Mal-PEG-NHS ester a powerful tool in pharmaceutical research and development.

Maleimide Peg NHS Ester has been extensively used in the development of protein conjugates, where it is used to link PEG chains to proteins or peptides through covalent bonding. The maleimide group selectively reacts with the thiol group on a cysteine residue in a protein, forming a stable thioether bond. The NHS ester group, on the other hand, can react with primary amines on the protein surface, such as lysine or N-terminus, to form an amide bond. The resulting PEG-protein conjugates exhibit improved stability, solubility, and pharmacokinetic properties, leading to enhanced therapeutic efficacy and reduced immunogenicity.

Mal-PEG-NHS ester has also been utilized in the development of targeted drug delivery systems. By conjugating Mal-PEG-NHS ester to a targeting molecule, such as an antibody or a peptide, it can be used to selectively deliver drugs to specific cells or tissues, improving the therapeutic index and reducing off-target effects.

Mal-PEG-NHS ester

Cat# Name Structure M.W. Purity Pricing
AP11448Mal-PEG1-NHS ester310.26≥95% Pricing
AP11449Mal-PEG2-NHS ester354.32≥95% Pricing
AP10054Mal-PEG3-CH2 NHS ester384.34≥95% Pricing
AP11450Mal-PEG3-NHS ester398.37≥95% Pricing
AP10698Mal-PEG4-NHS ester442.42≥95% Pricing
AP11451Mal-PEG5-NHS ester486.47≥95% Pricing
AP11452Mal-PEG6-NHS ester530.53≥95% Pricing
AP11453Mal-PEG8-NHS ester618.63≥95% Pricing
AP11454Mal-PEG12-NHS ester794.85≥95% Pricing

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