DSPE-PEG8-Mal contains a DSPE and maleimide group. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG linker can increase the water solubility of the overall compound allowing for the delivery of the drug. The maleimide group can react with thiol groups between a pH range of 6.5 to 7.5 to form a thiolester bond.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.