Folate-PEG-Mal(Folic Acid-PEG-Mal) is a functional group that has gained significant attention in the field of drug research and development. It is a water-soluble polymer consisting of a folate ligand, polyethylene glycol (PEG), and a maleimide (Mal) group. Folate-PEG-Mal has been utilized as a versatile tool for drug delivery and targeting applications, owing to its ability to selectively bind to folate receptors, which are overexpressed in many cancer cells.
The Mal group on the folate-PEG-Mal molecule also allows for facile conjugation with other biomolecules or therapeutic agents, making it an attractive option for the development of targeted drug delivery systems. In addition, the PEG component of folate-PEG-Mal provides improved solubility and circulation time of the conjugate in the body, enhancing its efficacy as a drug delivery system.