5-Maleimido-pentanoic NHS ester CAS:103750-03-4 is a chemical compound that is widely used in the field of pharmaceutical research and development. This compound contains an NHS ester group, which allows for the efficient and selective conjugation of biomolecules, such as proteins and peptides, to other molecules or surfaces. In particular, 5-Maleimido-pentanoic NHS ester is often used in the development of antibody-drug conjugates (ADCs), which are a type of targeted cancer therapy that combines the specificity of antibodies with the cytotoxicity of small-molecule drugs.
The maleimide functional group in 5-Maleimido-pentanoic NHS ester can selectively react with thiol groups in cysteine residues on antibodies, forming a stable and covalent bond between the antibody and the drug. This specific and controlled drug delivery mechanism can significantly improve the efficacy and safety of cancer treatments, making 5-Maleimido-pentanoic NHS ester a vital tool in the development of new therapeutics. Its unique chemical properties and versatility make it an essential component of modern pharmaceutical research, with the potential to transform the treatment of many diseases.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.