Mal-PEG12-acid linker contains a maleimide group with a terminal carboxylic acid. The PEG spacer increases the aqueous solubility of the resulting compound. The maleimide group reacts specifically with a thiol group to form a covalent C-S bond, enabling the bioconjugation with a thiol bearing molecules. The terminal carboxylic acid readily reacts with primary and secondary amine under EDC, DCC, HATU or other amide coupling conditions to form a stable amide bond.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.