Methyltetrazine-PEG12-maleimide is a click chemistry PEG maleimide molecule. Tetrazines will react with strained alkenes such as trans-cyclooctene; norbornene and cyclopropene produce stable covalent bonds. This reagent can be used to efficiently bind tetrazine moieties to TCO-linked compounds or macromolecules. Methyltetrazine has slower cycloaddition kinetics than hydrogen-substituted analogs; but also exhibits enhanced relative stability in biological environments. PEG linkers improve water solubility; reduced aggregation and increased distance between the thiol to be modified and the tetrazine.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.