Propargyl-PEG-Maleimide（Alkyne-PEG-Mal） contains a propargyl functional group (-C≡CH) and a maleimide functional group (-C2H2NCO) attached to the PEG chain. The propargyl group is known for its ability to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the maleimide group is reactive towards thiol-containing molecules.
Propargyl-PEG-Maleimide has been widely used in the development of drug conjugates and biomaterials. Its unique chemical properties allow for the site-specific conjugation of therapeutic agents, such as proteins and peptides, to the PEG chain via CuAAC reaction. The resulting conjugates exhibit improved stability, enhanced pharmacokinetic profile, and reduced immunogenicity, leading to improved therapeutic efficacy and safety.
Propargyl-PEG-Maleimide can be used as a crosslinking agent to modify biomaterials and improve their mechanical and biological properties. By reacting with thiol-containing molecules, such as cysteine residues on proteins, Propargyl-PEG-Maleimide can form stable and biocompatible linkages, leading to the formation of functionalized biomaterials for tissue engineering and regenerative medicine.