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Mal-amido-PEG-amine contains two important functional groups, namely a maleimide group (-Mal) and an amine group (-NH2).

The maleimide group is known for its ability to react selectively with thiol-containing molecules, such as cysteine residues in proteins, via a Michael addition reaction. This property allows for the specific conjugation of Mal-amido-PEG-amine to thiol-containing biomolecules, resulting in the formation of stable and well-defined conjugates.

The amine group is a versatile functional group that can be easily modified or conjugated with a wide range of functional molecules, such as carboxylic acids, aldehydes, and isocyanates. This makes Mal-amido-PEG-amine a useful tool for the development of drug delivery systems and biomaterials.

Mal-amido-PEG-amine has been utilized in the development of various drug delivery systems, such as antibody-drug conjugates (ADCs) and protein-polymer conjugates. In ADCs, the amine group of Mal-amido-PEG-amine is conjugated to the antibody via an amide bond, while the maleimide group is used to selectively conjugate a cytotoxic drug to the antibody via a thiol-maleimide reaction. This results in a highly specific and effective drug delivery system that targets cancer cells while sparing normal cells.


Cat# Name Structure M.W. Purity Pricing
AP10745Mal-amido-PEG2-amine299.32≥95% Pricing
AP11479Mal-amido-PEG9-amine TFA salt607.7≥95% Pricing
AP13273Mal-amido-PEG11-amine TFA salt809.8≥97% Pricing
AP13272Mal-amido-PEG23-amine1224.5≥98% Pricing

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