SMCC(N-succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate) CAS:64987-85-5 is a heterobifunctional crosslinker commonly used in the field of pharmaceutical research and development. This compound contains two functional groups: the succinimidyl ester group, which reacts with primary amines, and the maleimide group, which reacts with sulfhydryl groups.
SMCC Linker has been extensively utilized in the production of antibody-drug conjugates (ADCs), a class of targeted cancer therapies that combines the specificity of monoclonal antibodies with the potency of cytotoxic drugs. SMCC is used to link the antibody to the cytotoxic drug through a stable, covalent bond. This approach allows for the precise delivery of the cytotoxic drug to cancer cells, minimizing damage to healthy tissues and reducing the side effects associated with traditional chemotherapy.
In addition to its use in ADCs, SMCC has also been employed in the development of protein-protein conjugates and protein-nanoparticle conjugates. The maleimide group can react with cysteine residues on proteins, while the succinimidyl ester group can react with lysine residues. This allows for the precise control of the conjugation site and orientation, leading to improved stability and activity of the resulting conjugates.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.