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Mal-amido-PEG-TFP este contains two functional groups: a maleimide group and a trifluoromethylphenyl (TFP) ester group. The maleimide group (-NHCOCH=CH-) is known for its ability to react specifically with sulfhydryl (-SH) groups, while the TFP ester group can react with primary amines (-NH2) to form stable amide bonds.

Mal-amido-PEG-TFP ester is widely used in pharmaceutical research and development due to its unique chemical properties. The maleimide group can be used to specifically target cysteine residues in proteins, allowing for site-specific conjugation of PEG to proteins. This results in improved pharmacokinetics and biodistribution, and reduced immunogenicity of the protein-based therapeutics. The TFP ester group, on the other hand, can be used to conjugate PEG to amine-containing molecules such as peptides, small molecules, and drug candidates, thereby improving their solubility, stability, and pharmacokinetic properties.

Mal-amido-PEG-TFP ester has also been employed as a cross-linking agent for biomaterials and hydrogels, where it can be used to create stable and biocompatible networks that mimic the extracellular matrix and support cell growth and tissue regeneration.

Mal-amido-PEG-TFP ester

Cat# Name Structure M.W. Purity Pricing
AP11482Mal-amido-PEG2-TFP ester476.38≥95% Pricing
AP11483Mal-amido-PEG4-TFP ester564.49≥95% Pricing
AP11484Mal-amido-PEG8-TFP ester740.7≥95% Pricing
AP11485Mal-amido-PEG12-TFP ester916.91≥95% Pricing
AP11486Mal-amido-PEG24-TFP ester1445.55≥95% Pricing
AP13992Mal-amido-PEG36-TFP ester1974.20≥95% Pricing

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