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Mal-alkyl-NHS ester is a class of chemical compounds widely used in pharmaceutical research and development. This class of compounds contains a maleimide (Mal) functional group, an alkyl chain, and an N-hydroxysuccinimide (NHS) ester group.

The maleimide functional group is known for its high reactivity towards thiol groups (-SH) of proteins and peptides, forming stable thioether bonds. The alkyl chain acts as a linker, providing appropriate spacing between the maleimide group and the NHS ester group, which enables the conjugation of Mal-alkyl-NHS esters with a wide range of biomolecules.

The NHS ester group, on the other hand, is highly reactive towards amine groups (-NH2) of proteins, forming stable amide bonds. This unique reactivity allows for the selective conjugation of Mal-alkyl-NHS esters with amine-containing biomolecules, such as lysine residues in proteins or the N-terminus of peptides.

Mal-alkyl-NHS esters have found wide applications in pharmaceutical research and development, particularly in the development of antibody-drug conjugates (ADCs), which are a class of targeted cancer therapeutics. ADCs combine the targeting ability of monoclonal antibodies with the cytotoxicity of small molecule drugs. Mal-alkyl-NHS esters are used to selectively conjugate the small molecule drug to the antibody, resulting in a stable and highly specific therapeutic agent.

Mal-Alkyl-NHS ester

Cat# Name Structure M.W. Purity Pricing
AP14624N-(alfa-Maleimidoacetoxy)succinimide252.20≥95% Pricing
AP10146Mal NHS ester266.21≥95% Pricing
AP119485-Maleimido-pentanoic NHS ester294.26≥95% Pricing
AP10549Mal-C6-NHS ester308.29≥95% Pricing
AP15071SMCC334.30≥95% Pricing
AP114916-Maleimidocaproic acid PFP ester377.27≥95% Pricing
AP10550Mal-C11-NHS ester378.42≥95% Pricing

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