Mal-PEG-amine

Maleimide peg amine contains two functional groups, a maleimide group (-Mal) and an amine group (-NH2), attached to the opposite ends of a PEG chain.

Maleimide peg amine has been extensively utilized in the development of novel drug delivery systems and conjugation chemistry. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain via maleimide-thiol chemistry. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.

In addition to its use in drug delivery systems, Maleimide peg amine has also been employed as a crosslinking reagent in various biomedical applications. For example, it can be used to crosslink biomolecules, such as proteins and nucleic acids, to form stable conjugates that can be used in diagnostic assays or therapeutic interventions.