Methyltetrazine-PEG3-Maleimide linker has a stable methyltetrazine on one end and a maleimide on the other. The methyltetrazine is ideal TCO biorthogonal for conjugations. The maleimide moiety is used extensively in ADCs for conjugation with the free thiol group of biomolecules.
The PEG spacer can increase the solubility, minimizes the immunogenicity and improves pharmacokinetics of ADCs. The short PEG chain has shown to reduce aggregation of ADCs and prevent fluorophore quenching.
AxisPharm provides custom synthesis of tetrazine PEG linkers with various functional groups in high quality.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.