TCO-PEG5-amido maleimide enables simple and efficient tagging of TCO moiety onto thiol containing antibodies, cysteine-containing peptides and other thiol-containing biomolecules. The maleimide group specifically and efficiently reacts with thiols (sulfhydryl groups, -SH) at pH 6.5 to 7.5 to form stable thioether bonds. The hydrophilic polyethylene glycol (PEG) spacer arm improves solubility in aqueous buffers.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.