Alkyne PEG (Polyethylene Glycol Alkyne) is a versatile reagent with a terminal alkyne and a functional group, perfect for bioconjugation, click chemistry, and drug delivery. The alkyne easily reacts with azides to form stable triazole bonds, while the PEG spacer boosts water solubility and provides precise control over linker length. Researchers use it widely in ADC research, surface modification, and cell imaging.
Alkyne PEG
Alkyne PEG (Polyethylene Glycol Alkyne)
Overview Alkyne PEG is a versatile reagent with a triple-bond alkyne at one end and functional groups at the other. The alkyne makes it perfect for click chemistry and bioconjugation, while the PEG backbone adds flexibility and water solubility. Researchers use Alkyne PEG for drug delivery, surface modification, and advanced research. Key Features- Terminal Alkyne Group: The alkyne reacts easily with azides to form stable triazoles under mild conditions. This click chemistry reaction is highly efficient and produces very few side products.
- Bioisostere Advantage: The triazole bond mimics an amide bond, with minimal impact on the biological activity of linked molecules.
- Dual Functional Groups: Alkyne PEG has an alkyne on one end and another functional group on the other, allowing for further modifications.
- Defined PEG Spacer: The PEG spacer controls the length between functional groups and boosts water solubility. This helps in bioconjugation, ADC development, and cell imaging.
- Bioconjugation: Links proteins, peptides, or other molecules with minimal effect on their function.
- ADC Research: Enables precise linker lengths in Antibody-Drug Conjugates for better therapeutic performance.
- Cell Imaging: Used in labeling and tracking cells due to the stable triazole bond.
- Surface Modification: Improves biocompatibility and reduces protein sticking on surfaces.
- Drug Delivery: PEGylates drugs to increase solubility and reduce immune response.
- Chemical Formula: H-(OCH2CH2)n-OCH2C≡CH
- Functional Groups: Alkyne at one end, customizable group at the other
- Purity: 95% or higher
- Molecular Weight Options: Ranges from 500 to 20,000 Da
- Forms Available: Liquid or powder
- Storage: Store at -20°C, away from light and moisture
- Safety Tips: Use gloves and eye protection. Work in a well-ventilated space.
- Storage Instructions: Keep in a cool, dry, dark place.
- Disposal: Follow local regulations for chemicals.
- Catalog Details: Specify the desired weight and functional group.
- Packaging Options: Available in 1g, 5g, 10g, 25g, or bulk.
- Custom Orders: Different PEG lengths, weights, and modifications available on request.
- Azide PEG: Pairs well with Alkyne PEG for click chemistry.
- Carboxyl PEG: For further functionalization with amines.
- Amine PEG: Useful for coupling with carboxyl derivatives.