Propargyl-PEG-amine（Amine-PEG-Alkyne) contains an amine functional group (-NH2) attached to the end of a PEG chain via a propargyl linker (-C≡CH), which can be used for further chemical modifications through copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.mine-PEG-Alkyne)
The amine functional group of Propargyl-PEG-amine is known for its ability to react with various reactive groups, such as carboxylic acids, isocyanates, and aldehydes, allowing for the development of a wide range of functionalized PEG derivatives.
Propargyl-PEG-amine has been utilized in the development of drug conjugates, bioconjugation, and surface modification of various biomedical materials. The CuAAC reaction allows for the selective attachment of specific molecules, such as drugs or targeting ligands, to the PEG chain, resulting in improved drug solubility, stability, and pharmacokinetics.
