Propargyl-PEG-CH2CO2H contains a propargyl functional group (-C≡CH) and a carboxylic acid group (-CO2H) attached to the end of a PEG chain. The propargyl group is known for its ability to undergo click chemistry reactions.
Propargyl-PEG-CH2CO2H has been extensively utilized in the development of novel drug delivery systems, such as hydrogels and nanoparticles. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain via click chemistry reactions. The resulting conjugates exhibit improved stability, increased solubility, and enhanced therapeutic efficacy.
Propargyl-PEG-CH2CO2H has also been employed as a crosslinking agent in tissue engineering applications. It can be used to create 3D hydrogel networks that mimic the extracellular matrix of living tissues, promoting cell adhesion and proliferation.