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Propargyl-PEG-5-nitrophenyl carbonate is a chemical compound that belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains a propargyl functional group (-C≡CH) attached to one end of a PEG chain and a 5-nitrophenyl carbonate functional group at the other end. The propargyl group is known for its ability to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC).

Propargyl-PEG-5-nitrophenyl carbonate has been extensively utilized in the development of novel drug conjugates and diagnostic agents. Its unique chemical properties allow for the covalent attachment of therapeutic agents or imaging probes to the PEG chain via CuAAC reaction, resulting in stable and well-defined conjugates. The 5-nitrophenyl carbonate functional group can be cleaved under mild conditions, such as in the presence of amines, to release the attached agent at the targeted site, offering spatiotemporal control over drug delivery.

Propargyl-PEG-5-nitrophenyl carbonate has also been employed in the development of bioorthogonal chemistry-based diagnostic tools. The CuAAC reaction allows for the site-specific attachment of imaging probes to biological molecules, such as proteins or nucleic acids, enabling non-invasive detection and imaging of disease sites.

Propargyl-PEG-5-nitrophenyl carbonate

Cat# Name Structure M.W. Purity Pricing
AP12327Propargyl-PEG4-5-nitrophenyl carbonate397.38≥95% Pricing

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