Propargyl-PEG3-Tos linker contains a tosyl group and a propargyl group. The tosyl group can be easily replaced by thiol and amino group through a nucleophilic substitution.The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The PEG spacer increases the aqueous solubility of the resulting compound.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.