Propargyl-PEG8-bromide is a PEG linker bearing a propargyl group and a bromide group. The propargyl group readily reacts with azide-functionalized biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage. Bromo (Br) is an excellent leaving group and undergoes nucleophilic substitution reactions with thiol group and amine group. The increasing aqueous solubility derived from the PEG spacer makes it an ideal conjugation linker for biological applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.