Propargyl-PEG-bromide is a polyethylene glycol (PEG) derivative containing a propargyl functional group (-C≡CH) and a bromide ion (-Br) attached to the PEG chain.
The propargyl functional group is known for its unique reactivity towards azide groups, enabling the formation of bioorthogonal click chemistry reactions. This reaction can be used to attach a wide range of biomolecules, such as proteins, peptides, and nucleic acids, to the PEG chain via a stable triazole linkage. This approach has been extensively used in drug delivery systems, bioimaging, and diagnostic applications, due to its high selectivity and biocompatibility.
The bromide ion attached to the PEG chain can be easily substituted with other functional groups, such as amines, alcohols, or thiols, using a variety of nucleophilic substitution reactions. This property allows for the tailored design of bioconjugates with specific properties, such as increased water solubility, improved biocompatibility, and prolonged circulation time in vivo.