The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. And the azide undergoes copper free click chemistry with strained DBCO, BCN etc to form stable triazole. The intact propargyl can then undergo a copper catalyzed click chemistry with an azide-tagged biomolecule to furnish this elegantly controlled conjugation process.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.