Propargyl-PEG-(CH2)3-acid contains a propargyl functional group (-C≡CH) attached to the PEG chain and a carboxylic acid group (-COOH) at the end of a three-carbon linker. The propargyl group is known for its ability to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
Propargyl-PEG-(CH2)3-acid has been extensively utilized in the development of novel drug delivery systems, such as conjugates with antibodies or small molecules. Its unique chemical properties allow for the covalent attachment of therapeutic agents to the PEG chain via CuAAC reaction, leading to enhanced stability, solubility, and targeted delivery in vivo.
Propargyl-PEG-(CH2)3-acid has also been employed as a surface modifier in various biomedical applications. For example, it can be immobilized onto the surface of medical devices or implants to improve biocompatibility and reduce immune response.