Alkyne-ethyl-PEG1-t-Butyl ester linker contains an alkyne group and a t-butyl protected carboxyl group. The alkyne can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The protected carboxyl group can be deprotected under mild acidic conditions. The PEG spacer increases the aqueous solubility of the resulting compound.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.