Propargyl-PEG1-t-butyl ester is a PEG crosslinker with a propargyl group and a t-butyl protected carboxyl acid group on the ends. While the propargyl group can be reacted with azide-bearing compounds or biomolecules through Click Chemistry to yield a stable triazole linkage, under acidic conditions, the t-butyl ester can be easily converted to an acid group useful for further conjugations with amine bearing molecules. The increasing aqueous solubility derived from PEG spacer makes such linker an ideal conjugation linkers for biological applications.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.