Propargyl-PEG2-acrylate linker contains a propargyl group and an acrylate group. The propargyl group readily reacts with azide-bearing molecules via copper catalyzed azide-alkyne Click Chemistry to form a stable triazole linkage. The acrylate group enables easily reacts with thiol through Michael addition. The PEG spacer increases aqueous solubility of the resulting conjugates.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.