Propargyl-PEG-acid(Acid-PEG-Alkyne) is a chemical compound belonging to the class of polyethylene glycol (PEG) derivatives, which contains a carboxylic acid functional group (-COOH) attached to the end of a PEG chain via a propargyl linker (-C≡CH). The propargyl group is an alkyne functional group that allows for click chemistry reactions with azide-functionalized molecules.
The carboxylic acid group in Propargyl-PEG-acid offers a range of chemical reactivity, including the ability to form amide bonds with amino groups, ester bonds with hydroxyl groups, and covalent linkage to metal ions. It is also a negatively charged group at physiological pH, which can be exploited for targeted drug delivery via electrostatic interactions.
Propargyl-PEG-acid has been widely used in the development of various drug delivery systems, including polymeric micelles, liposomes, and nanoparticles. The click chemistry reaction between the propargyl group and azide-functionalized targeting ligands or drugs provides a facile method to incorporate specific functional moieties into the PEG chain, enabling the selective and efficient delivery of drugs to target sites.
