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Propargyl-PEG-methyl ester contains a propargyl functional group (-C≡CH) attached to the terminal carbon atom of a PEG chain, as well as a methyl ester group (-COOCH3) at the other end of the chain.

The propargyl functional group is known for its ability to undergo click chemistry reactions with azides, making Propargyl-PEG-methyl ester a useful tool in the field of pharmaceutical research and development. Click chemistry is a type of chemical reaction that is highly efficient, selective, and modular, allowing for the facile and rapid synthesis of complex molecules.

Propargyl-PEG-methyl ester has been extensively utilized in the development of novel drug conjugates, such as antibody-drug conjugates (ADCs) and enzyme-prodrug systems. The propargyl group can be selectively conjugated to an azide-functionalized therapeutic agent via click chemistry, resulting in the formation of a stable and covalent bond. The resulting conjugates exhibit improved pharmacokinetics, reduced toxicity, and enhanced therapeutic efficacy.

Propargyl-PEG-methyl ester

Cat# Name Structure M.W. Purity Pricing
AP11682Propargyl-PEG3-methyl ester230.26≥95% Pricing

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