The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The aldehyde group readily reacts with primary amines, aminooxy and hydrazide to form a reversible oxime or hydrazone linkage. The PEG spacer increase the solubility of the resulting complex in aqueous media.
AxisPharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.