Propargyl-PEG1-BocNH Tyrosine Methyl Ester is a bifunctional reagent that is commonly used in peptide chemistry and drug development. The reagent is composed of a propargyl group, a short polyethylene glycol (PEG) linker, a Boc-protected amine group, and a tyrosine methyl ester group.
The propargyl group is a highly reactive alkyne that can undergo copper-catalyzed click chemistry with azide-containing compounds, making it an ideal functional group for bioconjugation reactions. The PEG linker provides a hydrophilic spacer between the propargyl and Boc-protected amine groups, while the tyrosine methyl ester group is a commonly used amino acid derivative.
Propargyl-PEG1-BocNH Tyrosine Methyl Ester is used for the solid-phase synthesis of peptide conjugates and for the modification of proteins and other biomolecules. The Boc-protected amine group can be deprotected and used for the conjugation of other molecules, such as fluorophores or drug molecules, while the tyrosine methyl ester group provides additional chemical functionality for further modification.
Propargyl-PEG1-BocNH Tyrosine Methyl Ester is a white to off-white powder that is soluble in a range of polar solvents, such as DMF, DMSO, or methanol. It should be stored at -20°C in a dry and dark place to maintain its stability and quality.
Propargyl-PEG1-BocNH Tyrosine Methyl Ester is a versatile and widely used reagent in peptide chemistry and drug development. Its ability to undergo copper-catalyzed click chemistry and its hydrophilic PEG linker make it a popular choice among researchers for bioconjugation and drug delivery applications. The Boc-protected amine group and tyrosine methyl ester group provide additional chemical functionality and potential for modification, making this reagent a useful tool in chemical biology and drug discovery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.