Dibenzocycolctyne – DBCO Linkers can undergo copper free click chemistry Reaction via a strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides. The spontaneously conjugation with azide-modified biomolecules without the need for toxic Cu catalysts makes the DBCO reagents ideal for living cells and organisms study.
DBCO reagents are stable in a broad range of solvents. Functionalized DBCO linkers have broad scope of applications in conjugations, such as cell surface modification, cell imaging, ADC research and tumor targeting delivery, etc.
PEG modified DBCO linkers have improved aqueous solubility. AxisPharm offers PEGylated DBCO with defined spacer length to meet your bioconjugation needs.