Methyltetrazine-PEG6-amine HCl salt is a versatile and efficient bioconjugation reagent featuring a methyltetrazine moiety, a six-unit polyethylene glycol (PEG) spacer, and a primary amine functional group. Its hydrophilic PEG linker enhances solubility and biocompatibility, while the methyltetrazine group ensures rapid and selective reactions via bioorthogonal inverse electron-demand Diels-Alder (IEDDA) chemistry with strained alkynes or alkenes.
In pharmaceutical research and development, Methyltetrazine-PEG6-amine HCl salt is widely used for the site-specific labeling of biomolecules such as proteins, peptides, and nucleic acids. Its applications include the generation of antibody-drug conjugates, targeted drug delivery systems, and molecular imaging probes. The unique chemistry of this reagent allows for efficient conjugation without compromising the biological activity of the target molecule, facilitating the development of novel therapeutics and diagnostic agents.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.