Biotin-PEG4-methyltetrazine is a biotinylation reagent with an extended PEG spacer and a terminal methyltetrazine moiety. The tetrazine group readily reacts with TCO-tagged compounds to form a stable covalent bond through a ultrafast bioorthogonal reaction – TCO-tetrazine ligation. The hydrophilic PEG spacer can increase aqueous solubility of the biotinylated molecules and help minimize steric hindrance and provide extra flexibility with the binding to stravidin and avidin molecules.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.