Methyltetrazine-PEG5-methyltetrazine provides a homobifunctional PEG linker with methyltetrazine groups at both ends of a hydrophilic PEG5 spacer and specifically supports rapid bioorthogonal conjugation, molecular crosslinking, and functional biomaterial research through tetrazine ligation.
Key Features and Benefits
- Homobifunctional Linker: Provides two terminal methyltetrazine groups for connecting compatible molecules, surfaces, or materials.
- Dual Methyltetrazine Functionality: Two reactive tetrazine groups specifically enable bifunctional conjugation and crosslinking strategies.
- PEG5 Spacer: The hydrophilic PEG5 chain specifically provides flexible spacing between the two reactive terminal groups.
- Bioorthogonal Click Chemistry: Methyltetrazine groups react rapidly with compatible strained alkene and alkyne functionalities.
- IEDDA Reactivity: Supports inverse-electron-demand Diels–Alder (IEDDA) reactions with compatible partners such as trans-cyclooctene (TCO).
- Copper-Free Conjugation: Tetrazine ligation proceeds without a copper catalyst, supporting applications where metal-free reaction conditions are preferred.
- Rapid Conjugation: High tetrazine reactivity specifically supports efficient labeling, coupling, and molecular assembly workflows.
- Hydrophilic Spacer: The PEG5 segment improves spacing and hydrophilic character between conjugated molecular components.
Applications
- Tetrazine Click Chemistry: Supports rapid IEDDA reactions with compatible strained alkene and alkyne groups.
- Bioconjugation: Connects appropriately functionalized peptides, proteins, ligands, and other biomolecules.
- Molecular Crosslinking: Dual methyltetrazine groups support linking two compatible TCO-functionalized molecular components.
- Biomolecule Labeling: Useful for introducing labels or functional molecules through bioorthogonal tetrazine ligation.
- Polymer Functionalization: Supports crosslinking and modification of polymers containing compatible reactive groups.
- Surface Modification: Enables tetrazine-mediated coupling to appropriately functionalized surfaces and materials.
- Nanoparticle Functionalization: Supports modification and crosslinking of compatible nanoparticle systems.
- Biomaterial Research: Useful for developing functional materials using rapid, bioorthogonal conjugation chemistry.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions. Protect from prolonged light exposure.
- Handling: Protect from moisture, excessive heat, and prolonged light exposure. Minimize unnecessary exposure to reactive click-chemistry partners during handling.
Methyltetrazine-PEG5-methyltetrazine combines dual tetrazine functionality with a flexible PEG5 spacer, while its homobifunctional design supports rapid IEDDA conjugation, crosslinking, molecular assembly, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
