Tosylate PEG is a versatile, synthetic polymer that combines the properties of polyethylene glycol (PEG) with a tosylate (p-toluenesulfonate) functional group. This chemical compound is widely used in various applications within the fields of chemistry, biochemistry, and materials science.
Tosylate PEG is comprised of a linear PEG chain, The PEG portion of the molecule imparts hydrophilic properties to the compound, making it soluble in water and polar organic solvents. The tosylate group provides reactive functionality, allowing the molecule to be used as a coupling agent, linker, or initiator in various chemical reactions.
a. Bioconjugation: Tosylate PEG is used as a linker to conjugate biomolecules, such as proteins, peptides, and nucleic acids, for improved stability, solubility, and bioavailability.
b. Drug delivery: The PEGylation of drug molecules using Tosylate PEG has been shown to increase the circulation time of drugs in the body, resulting in enhanced therapeutic efficacy and reduced side effects.
c. Polymer synthesis: Tosylate PEG can serve as a chain transfer agent or initiator in the synthesis of block copolymers, hydrogels, or other functionalized polymers.
d. Surface modification: Tosylate PEG can be used to modify surfaces, such as nanoparticles or medical devices, to improve their biocompatibility and reduce nonspecific interactions with biological systems.
- (S,R. S)-AHPC-PEG-tosyl
- Branched PEG Tosylate
- Ms-PEG-t-butyl ester
- Other PEG Tosylates
- Tos-PEG-methyl ester
- Tos-PEG-t-butyl ester