Thalidomide-O-PEG5-Tosyl CAS:2414905-34-1 is an innovative compound that combines the properties of thalidomide, a polyethylene glycol (PEG) chain with five ethylene oxide (EO) repeating units (PEG5), and a tosylate (p-toluenesulfonate) functional group. This conjugate is designed to enhance the therapeutic potential of thalidomide by improving its solubility, bioavailability, and biocompatibility through the incorporation of PEG5 and the tosylate group, offering potential for improved drug delivery systems and bioconjugation applications in pharmaceutical and biomedical research.
Structure: Thalidomide-O-PEG5-Tosyl consists of a thalidomide molecule conjugated to a PEG chain with five ethylene oxide units (PEG5) through an oxygen atom (O), with a tosylate group at the other end of the PEG5 chain. Thalidomide is a synthetic drug with immunomodulatory and anti-inflammatory properties, PEG5 is a short hydrophilic polymer chain, and the tosylate group is derived from p-toluenesulfonic acid.
Properties: The conjugation of thalidomide to PEG5 imparts hydrophilic properties to the molecule, improving its solubility in water and polar organic solvents. This increased solubility can enhance the bioavailability of thalidomide in the body. The tosylate group provides a reactive functionality, enabling further chemical modifications or conjugations with other biomolecules.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.