Tos-PEG-CH2CO2H contains a tosyl functional group (-Ts) and a carboxylic acid group (-CO2H) attached to the PEG chain.
Tos-PEG-CH2CO2H has been widely used in the field of pharmaceutical research and development due to its ability to modify biomolecules and improve their properties. For example, it can be used to modify proteins or peptides by attaching the PEG chain through the carboxylic acid group, resulting in enhanced stability, solubility, and pharmacokinetic properties.
In addition to its use in protein modification, Tos-PEG-CH2CO2H has also been employed in the development of drug delivery systems. Its tosyl group can be used to conjugate with a variety of nucleophiles, such as amine groups on drugs, to form covalent bonds. This allows for the efficient loading and targeted delivery of drugs to specific sites in the body, leading to improved therapeutic efficacy and reduced toxicity.