Tos-PEG-acid contains a tosyl functional group (-OTs) attached to one end of a PEG chain, and a carboxylic acid functional group (-COOH) attached to the other end.
The tosyl group is known for its ability to react with nucleophiles such as amines, thiols, and alcohols, making it useful for the covalent attachment of bioactive molecules to the PEG chain. The carboxylic acid group, on the other hand, provides the opportunity for Tos-PEG-acid to participate in various chemical reactions, such as amidation and esterification.
Tos-PEG-acid has been widely utilized in the development of drug delivery systems, such as liposomes, micelles, and nanoparticles. Its unique chemical properties allow for the conjugation of bioactive molecules, such as drugs, peptides, and proteins, to the PEG chain via covalent bonds. The resulting conjugates exhibit improved solubility, stability, and bioavailability, leading to enhanced therapeutic efficacy and reduced toxicity.