PEG-Tos is a chemical compound that belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains a tosylate functional group (-OTs) attached to the end of a PEG chain.
PEG-Tos has been extensively utilized in the development of novel drug delivery systems, such as prodrugs, polymer-drug conjugates, and targeted therapeutics. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as small molecules, peptides, and proteins, to the PEG chain via nucleophilic substitution. The resulting conjugates exhibit improved pharmacokinetic and pharmacodynamic profiles, leading to enhanced therapeutic efficacy and reduced toxicity.
PEG-Tos has also been employed as a surface modifier in various biomedical applications. For example, it can be immobilized onto the surface of nanoparticles or microspheres to improve stability and reduce immune response.