Tos-PEG-Tos consists of two tosyl (Tos) functional groups attached to each end of a PEG chain.
Tos-PEG-Tos has been extensively utilized in the development of novel drug delivery systems, such as dendrimers, liposomes, and nanoparticles. Its unique chemical properties allow for the selective attachment of therapeutic agents, such as drugs or proteins, to the PEG chain via Tos groups. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.
Tos-PEG-Tos has also been employed as a linker in various biomedical applications. For example, it can be used to cross-link biomolecules or to attach biomolecules onto surfaces, allowing for the development of novel biomaterials.