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Trifluoroethyl-PEG-Tos is a polyethylene glycol (PEG) derivative that contains a tosylate functional group (-OTs) attached to a trifluoroethyl group (-CF3) at one end of the PEG chain. The tosylate group is a commonly used leaving group in organic chemistry, which allows for various reactions and modifications of the PEG chain.

Trifluoroethyl-PEG-Tos has been extensively utilized in pharmaceutical research and development, particularly in the field of drug delivery systems. It can be used as a precursor for the synthesis of various PEG-based prodrugs, which are biologically inactive compounds that are converted into active drugs in vivo. The tosylate group can be easily displaced by nucleophiles, such as amino groups or thiol groups, allowing for the conjugation of therapeutic agents to the PEG chain via covalent bonds.

In addition to its use in prodrug synthesis, Trifluoroethyl-PEG-Tos can also be used as a linker for the conjugation of various molecules, such as imaging agents or targeting ligands, to PEGylated drugs. This allows for the development of targeted drug delivery systems, where the drug is selectively delivered to a specific tissue or cell type, leading to improved therapeutic efficacy and reduced toxicity.

Cat# Name Structure M.W. Purity Pricing
AP119061,1,1-Trifluoroethyl-PEG5-Tos430.44≥95% Pricing

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