TCO-PEG4-Fmoc-Gly-Gly-GlyTCO contains a TCO group and a Gly-Gly-Gly peptide residue. The Fmoc-Gly-Gly-Gly peptide cleaves specifically with cathepsin B enzyme. TCO can be utilized for conjugation with tetrazine tagged biomolecules.
TCO-PEG4-Fmoc-Gly-Gly-Gly is a peptide sequence composed of three glycine (Gly) amino acids. The first amino acid, TCO, is a thiocarboxylic acid, and the second amino acid, PEG4, is a polyethylene glycol (PEG) with a molecular weight of 4,000 Da. The third and following amino acids are Fmoc-Gly-Gly-Gly, which stand for Fluorenylmethyloxycarbonyl-Glycine-Glycine-Glycine. Fmoc is a protecting group which prevents the glycines from undergoing any reactions, and allows them to remain in the peptide sequence without modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.