N-Methylaniline-PEG-TCO contains a tetrazine cyclooctyne (TCO) functional group and a N-methylaniline moiety.The TCO functional group is known for its ability to react with tetrazine-containing molecules, forming highly stable covalent bonds through a bioorthogonal chemical reaction. This property makes N-Methylaniline-PEG-TCO a valuable tool for the development of targeted drug delivery systems, as it allows for the selective attachment of therapeutic agents to specific cell types or tissues.
The N-methylaniline moiety, on the other hand, offers several advantages in terms of solubility and bioactivity. It enhances the solubility of the compound in both aqueous and organic solvents, making it easier to handle and formulate into drug delivery systems. Moreover, N-methylaniline is known for its ability to act as an electron donor or acceptor in biological systems, which can enhance the pharmacological properties of the attached therapeutic agent.