Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. The cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported. It has had many reported applications in biological labeling and imaging.
TCO-PEG1-OH is a commonly used tool for Click Chemistry reactions due to the strain of the molecule. The hydroxyl group allows for additional reactions to take place to further derivatize the compound.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.