The aldehyde group readily reacts with primary amines, aminooxy and hydrazide to form a reversible oxime or hydrazone linkage. TCO Linkers are bioorthogonal agents for tetrazine. It reacts specifically with tetrazine tagged biomolecules in an ultrafast mode. The PEG spacer increase the solubility of the resulting complex in aqueous media.
AxisPharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.