TCO-OH is a crucial building block for TCO reagents in the TCO-tetrazine ligation process. The TCO-Tz ligation is based on an inverse demand Diels-Alder cycloaddition reaction between a trans-Cyclooctene and tetrazine reaction pair, forming a dihydropyridazine bond. The TCO-Tz ligation possess is selective with ultrafast kinetics (> 800 M-1s-1) and unmatched by any other bioorthogonal ligations.
AxisPharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.