Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. The cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported. It has had many reported applications in biological labeling and imaging.
TCO-OH is a crucial building block for TCO reagents in the TCO-tetrazine ligation process. The TCO-Tz ligation is based on an inverse杁emand Diels朅lder cycloaddition reaction between a trans朿yclooctene and tetrazine reaction pair, forming a dihydropyridazine bond. The TCO朤z ligation possess is selective with ultrafast kinetics (> 800 M?s?) and unmatched by any other bioorthogonal ligations.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.