TCO-PEG Linkers enable fast, efficient bioorthogonal reactions for bioconjugation, molecular imaging, and cell diagnostics. The TCO-tetrazine reaction works at unmatched speed in bioorthogonal chemistry. PEG spacers improve solubility, reduce aggregation, and enhance drug stability. Use them for quick and precise modifications in research and drug development.
TCO PEG
TCO-PEG Overview
TCO-PEG Linkers are essential bioorthogonal agents for tetrazine reactions. The TCO-tetrazine cycloaddition happens at an ultrafast speed, making it highly effective for bioconjugation, molecular imaging, and cell-based diagnostics. This reaction stands out with unmatched kinetics in bioorthogonal chemistry. Hydrophobic TCOs often lose activity due to interactions with monoclonal antibodies (mAbs). However, adding PEG spacers minimizes these interactions. The PEGylation improves solubility, reduces aggregation, and enhances pharmacokinetic and pharmacodynamic properties.Key Features:
- Ultrafast Ligation: TCO-tetrazine reactions happen quickly and efficiently.
- PEG Spacers: Increase solubility and reduce unwanted interactions with mAbs.
- Enhanced Stability: PEGylation boosts the pharmacokinetics and reduces immunogenicity.
Applications:
- Bioconjugation: Perfect for quick and selective labeling of proteins and peptides.
- Molecular Imaging: Ideal for precise, fast molecular tracking in imaging.
- Cell Diagnostics: Efficient for use in cell-based diagnostic applications.
Advantages:
- Rapid Reactions: TCO-tetrazine ligation offers the fastest bioorthogonal chemistry available.
- Improved Solubility: PEGylation increases water solubility and reduces mAb aggregation.
- Better Drug Delivery: PEG boosts the pharmacokinetics and reduces immune response for enhanced therapeutic effects.