Biotin PEG Linkers: Essential Tools for Accurate Purification and Detection
Biotin PEG linkers are invaluable in molecular biology and biochemistry for non-radioactive purification, detection, immobilization, labeling, and targeting. Combining the high affinity of biotin (vitamin H) with the solubility benefits of polyethylene glycol (PEG), these linkers form highly stable complexes with avidin and streptavidin, even under extreme conditions like varying pH, temperature, and organic solvents.
Why Choose Biotin PEG Linkers from AxisPharm?
- Versatility: Our biotinylation reagents feature a range of functional groups, catering to diverse research applications.
- Enhanced Solubility: The PEG spacer improves solubility, reducing toxic or immunological effects for more reliable results.
- Precise Control: Mono-dispersed PEG linkers allow precise control over spacer length, optimizing performance in biotin-binding assays with streptavidin, avidin, and other avidin proteins.
Key Features:
- Strong Binding Affinity: Rapid and specific interaction with avidin and streptavidin ensures stable complex formation.
- Stable Complexes: Maintains stability under extreme conditions, including changes in pH, temperature, and solvents.
Applications:
- Purification: Non-radioactive purification of biomolecules.
- Detection: Enhanced sensitivity and specificity in detection assays.
- Immobilization: Effective immobilization of biotinylated molecules for various applications.
- Labeling: Precise protein biotinylation labeling for tracking and analysis.
- Targeting: Specific targeting in biological assays and experiments.
Choosing the right biotinylation reagent involves considering solubility, spacer length, reversibility, and functional group compatibility. AxisPharm provides a comprehensive range of biotin PEG linkers, ensuring you find the perfect solution for your research needs.
Ref:
Chaturvedi R, Kang Y, Eom Y, Torati SR, Kim C.
Functionalization of Biotinylated Polyethylene Glycol on Live Magnetotactic Bacteria Carriers for Improved Stealth Properties. Biology (Basel). 2021 Oct 1;10(10):993.
Universal Biotin–PEG-Linked Gold Nanoparticle Probes for the Simultaneous Detection of Nucleic Acids and Proteins Alexander W. Scott, Viswanadham Garimella, Colin M. Calabrese, and Chad A. Mirkin Bioconjugate Chemistry 2017 28 (1), 203-211
Ultimate Guide to Choosing the Right Biotin PEG Linker
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