D-Biotin-PEG6-Thalidomide is a cereblon affinity probe for PROTAC and targeted protein degradation research. It can be used in cereblon (CRBN) binding and displacement assays for protein degrader validation experiments, CRBN ligand discovery, competition analyses, or where enrichment of CRBN complexes is required. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.