Peptide PEG linkers are protease-sensitivity linkers (also called enzymatically cleavable linkers). They comprise of either a di-, tri- or tetra-peptide that is recognized and cleaved by lysosomal enzymes to ensure the intracellular drug release once the ADC antibody-drug conjugates is internalized to the lysosome. The PEG moiety improves the aqueous solubility of the resulting bioconjugate and helps avoid protein aggregation.
AxisPharm has a large collection of PEGylated peptide synthesis reagents in stock. Custom syntheses of peptide PEG are available upon request.